You can always roll back the settings from the TCP Optimizer "Windows Default" radio button, or reset Winsock and TCP/IP from the File menu and start fresh.
Still, note that cell broadband/tethering is unreliable, you are prone to a lot of traffic spikes, lag, interference, etc. It depends on many factors. Still, try with the TCP Optimizer default and optimal settings, and see if that makes a difference, that's a good start.
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