The Task Manager should provide some more info... In the list of processes, sort by disk usage (just click on the "Disk" heading). Also, under the "Performance" tab, tick the appropriate disk in the left column, then at the bottom open "Resource Monitor", it should list processes with disk activity and show more info on them.
If the amount of data is not much, it could be the HDD going bad (having issue reading some sectors, etc.), but I'd rule out other options first.
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