For the best overall gaming experience, you have to use the "optimal" settings and apply them first, then in the "Advanced" tab you have to disable Naggle's algorithm and set the "Network Throttling index".
Step by step instructions are available here:
http://www.speedguide.net/faq/35-wha...ttings-for-474
You may also want to look at the "Gaming tweaks" article linked in the above FAQ.
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