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Your RWIN value seems too high for that type of connection, I'd use no more than 261120.
As far as the MTU, you can try the Optimizer's "MTU" tab to find the Max MTU available to you, it is dependent on your ISP and the type of connection. It is not as important as the RWIN value.
Ultimately, it depends on your ISP's feed, so optimizing your end of the connection is just a part of the solution.
You will probably get more responses and suggestions in the Tweaking forum.
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