Block WAN Request: Enable (hides you better)
Multicast Pass Through: Enable (for various types of multimediamedia traffic/streaming)
IPSec Pass Through: Enable Disable (If you VPN to a main office have it on)
PPTP Pass Through: Enable Disable (If you VPN to a main office have it on)
Remote Management: Disable Port: 8080
Remote Upgrade: Disable
MTU: Enable Disable Size1500 if on bridged DSL or cable, 1492 if on PPPoE DSL)
Filter Internet NAT Redirectionisable (for testing of local LAN servers using "loopback" WAN IP. )
Filter IDENT(port 113): if you use some chat programs like mIRC...toggling this can help.
Most of these the default setting should be fine. The only ones I'd worry about are making sure remote management and remote upgrade is disabled, and locking down MTU based on whatever type of broadband I have.